Abstract: Slide Presentations |


Hakim A. Ali, MD*; Arshad A. Wani, MD; Ghulam Khaleeq, MD
Author and Funding Information

Albert Einstein Medical Center, Philadelphia, PA


Chest. 2008;134(4_MeetingAbstracts):s47003. doi:10.1378/chest.134.4_MeetingAbstracts.s47003
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PURPOSE:Pulmonary thromboembolic disease is a major healthcare concern. The highly sensitive quantitative D-dimer (hs D-dimer) assay has a high negative predictive value for thromboembolic disease at normal values. The significance of elevated D-dimer is not so clear.

METHODS:We did a retrospective observational analysis to look for the diagnoses associated with various levels of hs D-dimer. We collected all patients who had elevated hs D-dimer levels during two separate 3 month intervals. The data collected included the age, symptoms at presentation that prompted the D-dimer test, further investigations prompted by the D dimer levels and the discharge diagnosis. We divided the patients into 5 groups depending on the hs D-dimer levels. (Groups I-V with hs D-dimer levels of 499-1000, 1001–3000, 3001–6000, 6001–9000,> 9000 respectively).

RESULTS:We included 230 patients. The two predominant symptoms that prompted a D-dimer test were shortness of breath in 84% patients and Chest pain in 56%. About 10% patients had leg symptoms including swelling or pain. 61% patients had a major risk factor for pulmonary embolism. In 78% patients additional tests were done to rule out a pulmonary embolism. The majority of D-dimer values were in the intermediate high range (1000–3000) .The major diagnoses in each group are shown in table 1. Only 3% of patients had a diagnosis of PE or DVT.

CONCLUSION:D-dimer is a very commonly used test particularly in the emergency room setting. A positive d dimer adds significantly to the cost of hospital visit. CHF and chronic lung disease were the most common diagnoses in patients with high levels. Very high D-dimer levels are not predictive of any particular diagnosis but were more commonly associated with thromboembolic disease, neoplasia or sepsis.

CLINICAL IMPLICATIONS:A wide variety of clinical conditions lead to increased D-dimer levels.Further studies are required to assess the importance of very high D-dimer values. Routine use of D-dimers in the evaluation of symptoms like shortness of breath and chest pain should be avoided.

DISCLOSURE:Hakim Ali, None.

Tuesday, October 28, 2008

2:30 PM - 4:00 PM




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