PURPOSE:Sarcoidosis is a chronic, multisystem granulomatous disease with highly variable natural history, prognosis and response to treatment. Symptom of fatigue is very well recognized problem in number of diseases including sarcoidosis. In most chronic diseases fatigue is associated with poor quality of life. Aims of this study were to analyze the impact of fatigue on the quality of life of patients with sarcoidosis and to detect the possible association of this symptom with other physiological variables.
METHODS:Prospective cross sectional study conducted at Wayne State University Health Center from December 2005 to April 2008. Patients were given two different questionnaires to evaluate their Health Related Quality of Life (HRQL). These data were correlated with pulmonary function tests and 6minute walk test results, after controlling for demographic variables and clinical parameters.
RESULTS:125 patients participated in study. 92% patients had biopsy proven sarcoidosis. 70% patients were female and 90% patients were African American. In uni-variate analysis fatigue was correlated well with gender (p 0.018), physical health component of SF-36 (p= 0.000), mental component of SF-36 (p 0.000) and Total SF-36 score (p= 0.000). In multivariate analysis fatigue attained a significant association with physical health components of SF-36 (p= 0.000), mental components of SF-36 (p= 0.004) and Total SF-36 score (p= 0.005).
CONCLUSION:Fatigue or lack of energy is very important symptom in Sarcoidosis. Fatigue correlate well with both domains of SF-36 and associated with a poor quality of life. Even, after adjustment for age sex and BMI patients, fatigue attains a significant predictor of poor quality of life in this subset of patients, irrespective of their stage of sarcoidosis, steroid use and abnormality in PFT or in six minute walk test results.
CLINICAL IMPLICATIONS:All patients with sarcoidosis should be evaluated for fatigue or lack of energy. As fatigue is very well correlated with their quality of life all efforts should be done to improve their fatigue.
DISCLOSURE:Bhavinkumar Dalal, No Financial Disclosure Information; No Product/Research Disclosure Information