PURPOSE: There are increasing concerns in many countries about the problem of drug resistant(DR) tuberculosis. Prevalence of primary drug resistance(PDR)tuberculosis is the optimal epidemiologic indicator for long term monitering of national tuberculosis control issues. Our purpose was to assess clinical characteristics and socioeconomic status of patients with DR-tuberculosis.
METHODS: The study was included 68 cases of DR Mycobacterium tuberculosis infection at one of university hospital based setting located in large capital city. Clinical profile and epidemiologic data were recruited retrospectively between PDR and acquired DR(ADR).
RESULTS: Patients with PDR were younger(40±16 years vs. 48±17 years), had more population under 40 years age(63% vs. 36%) and were highly educated(39% vs. 11%)than those with ADR. In patients with ADR, the rates of familial history of tuberculosis and living in rented house residence were shown higher than PDR. Patients of ADR had involved more lobes(2.0±0.8 vs. 1.4±0.7) and longer treatment duration(18±7 months vs. 10±6) than those of PDR. Patients with ADR showed resistance to more number of drugs, lower hospitalization rate and higher rate of self interuption of medication than PDR. In patients with PDR, mono drug resistance was higher in incidence, whereas poly- and multi-DR were lower comparing to ADR. Resistance to isoniazid was the highest among antituberculosis drugs, especially in ADR group.
CONCLUSION: Patients with ADR were more likely to include more population of lower socioeconomic class, whereas patients with PDR seemed to be young and socially active population. There was different epidemiologic background between PDR and ADR.
CLINICAL IMPLICATIONS: For the control of drug resistant tuberculosis, especially in large city, family based proper education, economical support for the treatment, and other preventive processes are required.
DISCLOSURE: Jung Chang, No Financial Disclosure Information; No Product/Research Disclosure Information