PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a disease with high mortality without known curative treatment. The aetiology is probably complex and cigarette smoking may be a risk marker according to a previous case-control study.
METHODS: We investigated a national sample of 172 cases with severe pulmonary fibrosis, among which 133 were judged as having IPF, and 745 randomly sampled controls from the general population. The cases were obtained from the Swedish Oxygen Register. All participants answered a postal questionnaire about smoking habits. We paid attention to smoking history five years before diagnosis among the cases and from a randomized anchor year among the controls. We analyzed odds ratios (OR) with logistic regression, adjusted for occupation, age and sex.
RESULTS: We found a significant association between severe pulmonary fibrosis and smoking among men (OR=3.5, 95% CI 1.9–6.2), but not for women (OR=1.2, 95% CI 0.7–2.1).
CONCLUSION: Smoking is associated with severe pulmonary fibrosis in men, but not in women.
CLINICAL IMPLICATIONS: Our finding supports the results of the previous study and adds additional argument to reduce smoking worldwide.
DISCLOSURE: Torbjorn Gustafson, None.