PURPOSE:Bronchoscopic palliative treatment is a modalitythat could reduce the symptoms in patients with inoperable lungcancer. Our interest is to study the palliative effect ofintrabronchial chemotherapy using cisplatin, in patients withinoperable lung cancers.
METHODS:Between the years of 2003 and 2008,patients with unresectable lung cancer and endobronchial lesionwere selected for tumor debulking via intrabronchial injection ofcisplatin. After flexible bronchoscopy, maximum 20mL cisplatinwith the concentration of 50 mg/100mL was injected into thebulk of the tumor through the special needle. The procedure wasperformed weekly for 4 sessions. After the end of fourth session,this procedure was done monthly. Patients were followedaccording to the symptoms, size of the involved lumen, andchanges in the shape and size of intrabronchial lesion after localchemotherapy.
RESULTS:A hundred thirty patients were studied (90 men, 40 women). All of them diagnosed with inoperable lung cancer. Accordingto the histology, they were categorized as adenocarcinoma (n=56), squamous cell carcinoma (n=43), and nonsmall celllung cancer, unspecified (n=31). At the end of the forth sessionof local chemotherapy, the involved lumen was considerablyopened (more than 25%) in 107 patients.
CONCLUSION:We suggest that intratumoral injection of cisplatincould reduce the severe symptoms of airway obstruction,hemoptysis (massive or nonmassive), and postobstructionpneumonias in patients with inoperable lung cancer and could be used for debulking of the tumor in the caseswith inoperable lung cancer.
CLINICAL IMPLICATIONS:There is no clinical implicaction.
DISCLOSURE:Hamidreza Jabbardarjani, None.