PURPOSE:The purpose of this study was to assess the diagnostic efficacy, tissue size and side effects between flexible bronchoscopic cryobiopsy and forcep biopsy in patients with lung cancer.
METHODS:from May 2007 to october 2007, 20 non-small cell lung cancer patients (squamous cell carcinoma 15 patients, adenocarcinoma 5 patients)with endobronchial lesion(nodular or polypoid) under bronchoscopy were enrolled. Firstly, the patients underwent routine flexible bronchoscpy with standard forcep biopsy. After then, bronchoscopic cryobiopsy was performed using a flexible cryoprobe(ERBE USA Inc.,Marietta, Ga.,USA). The cryoprobe was activated with a foot pedal until iceball appear (within 30 s), then to remove tissue from tumor, the probe was retracted after release of the foot pedal using probe-tissue adherence.
RESULTS:: A size of specimen in cryobiopsy was significantly larger compared to forcep biopsy (2.0±1.2mm, 6.0±3.0mm, respectively p=0.001). The diagnostic rate in forcep biopsy and cryobiopsy were 75%(15/20), 95%(19/20), respectively(p=0.06). No major complications occurred in both group.
CONCLUSION:Flexible bronchoscopic cryobiopsy was safe diagnostic method and may be helpful to get large tissue from endobronchial lesion.
CLINICAL IMPLICATIONS:tissue culture, anticancer drug susceptibility, prognosis.
DISCLOSURE:Chulho Oak, No Financial Disclosure Information; No Product/Research Disclosure Information