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Abstract: Poster Presentations |

PATIENTS UNDERGOING CORONARY ANGIOGRAPHY BECAUSE OF CHEST PAIN WITH HEPATITIS C VIRUS SEROPOSITIVITY HAVE A HIGHER PREVALENCE OF OBSTRUCTIVE CORONARY ARTERY DISEASE THAN A CONTROL GROUP FREE TO VIEW

Amit Asija, MD*; Wilbert S. Aronow, MD; Navindra Ramdeen, MD; Savneek Chugh, MD
Author and Funding Information

New York Medical College, Valhalla, NY


Chest


Chest. 2008;134(4_MeetingAbstracts):p87002. doi:10.1378/chest.134.4_MeetingAbstracts.p87002
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Abstract

PURPOSE:To investigate in patients seropositive for hepatitis C virus and in an age-and sex-matched control group with similar coronary risk factors undergoing coronary angiography because of chest pain the prevalence of obstructive coronary artery disease (CAD).

METHODS:The patients included 31 men and 5 women, mean age 53 ± 9 years, seropositive for hepatitis C virus and 31 men and 5 women, mean age 53 ± 9 years, seronegative for hepatitis C virus undergoing coronary angiography because of chest pain. Coronary risk factors were not significantly different between the 2 groups. Obstructive coronary artery disease (CAD) was >50% obstruction of at least 1 major coronary artery.

RESULTS:Obstructive CAD was present in 32 of 36 patients (89%) seropositive for hepatitis C virus and in 21 of 36 patients (58%) seronegative for hepatitis C virus (p<0.005). 3-vessel obstructive CAD was present in 9 of 36 patients (25%) seropositive for hepatitis C virus and in 2 of 36 patients (6%) seronegative for hepatitis C virus (p<0.025). 2-vessel or 3-vessel obstructive CAD was present in 21 of 36 patients (58%) seropositive for hepatitis C virus and in 9 of 36 patients (25%) seronegative for hepatitis C virus (p<0.005.

CONCLUSION:Patients undergoing coronary angiography for chest pain have a significantly higher prevalence of obstructive CAD, of obstructive 3-vessel CAD, and of obstructive 2-vessel or 3-vessel CAD if they are seropositive for hepatitis C virus than if they are seronegative for hepatitis C virus.

CLINICAL IMPLICATIONS:Patients with hepatitis C virus should have intensive coronary risk factor modification.

DISCLOSURE:Amit Asija, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, October 29, 2008

1:00 PM - 2:15 PM


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