PURPOSE:Published reports have shown that Asian-Indians (AI's) have a higher rate of coronary artery disease (CAD) than other ethnic groups. Coronary artery diameter appears to be smaller in AI's, possibly contributing to the higher occurrence of CAD in this population. To date, mixed results have been reported; many have analyzed differences between only two ethnic groups (i.e. AI and Caucasian).
METHODS:Here we explored the differences in the sizes of coronary arteries between AI's, Caucasians and African-Americans (total n=273). Multivariate ANOVA was performed for ethnicity predicting to the left main, left anterior descending, left circumflex and right coronary artery diameter sizes. In a subset of patients with risk factor data available (total n=127), a second multivariate ANOVA was performed including history of hypertension, BMI and BSA. These groups were matched on age, gender and hypercholesterolemia.
RESULTS:Ethnic group significantly predicted diameter (p<.05) of all arteries; in the group with risk factor data available, the left anterior descending and left circumflex were still significantly smaller after controlling for other risk factors.
CONCLUSION:These results provide further support that artery sizes are smaller in AI's than in Caucasians and African-Americans, even after taking into account other important risk factors, possibly contributing to the higher occurrence of CAD in this population.
CLINICAL IMPLICATIONS:These results add to the knowledge base regarding the the many possible reasons why AI are especially prone to CAD. When treating AI's, this risk factor should be kept in mind.
DISCLOSURE:Subir Labana, None.