PURPOSE:To investigate the association between QRS duration on the resting electrocardiogram (ECG) with severity of coronary artery disease (CAD) in patients undergoing coronary angiography for suspected CAD.
METHODS:We investigated the prevalence of a QRS duration ≥ 120 milliseconds on the resting ECG in patients with no CAD, nonobstructive CAD, 1-vessel obstructive CAD, 2-vessel obstructive CAD, and 3-vessel obstructive CAD undergoing coronary angiography for suspected CAD. The 2,196 patients included 1,291 men and 905 women, mean age 69 ± 10 years, with suspected CAD. Nonobstructive CAD was diagnosed if there was <50% obstruction of 1 major coronary artery. Obstructive CAD was diagnosed if there was >50% obstruction of at least 1 major coronary artery.
RESULTS:A QRS duration of ≥ 120 milliseconds on the resting ECG was present in 30 of 220 patients (14%) with no CAD,1 in 44 of 276 patients (16%) with nonobstructive CAD,2 in 76 of 441 patients (17%) with 1-vessel CAD,3 in 99 of 464 patients (21%) with 2-vessel CAD,4 and in 217 of 795 patients (27%) with 3-vessel CAD5 (p <0.001 comparing 5 with 1, 5 with 2, and 5 with 3; p<0.02 comparing 5 with 4 and 4 with 1).
CONCLUSION:The prevalence of a QRS duration ≥ 120 milliseconds on the resting ECG increased with increasing severity of obstructive CAD.
CLINICAL IMPLICATIONS:Patients with a QRS duration ≥ 120 milliseconds on the resting ECG have a greater severity of obstructive CAD.
DISCLOSURE:Kiran Chilappa, No Financial Disclosure Information; No Product/Research Disclosure Information