PURPOSE: Carcinoid tumors are divided into typical and atypical types. The treatment of choice is surgical resection and the postoperative long- term survival is good in most patients. Our objective was studying patients with carcinoid tumor who had undergone surgery.
METHODS: This is a study which was performed from 1990 through 2007 on 40 patients with carcinoid tumor who had surgery and had been followed up for at least 3 years. The statistical analyses where based their age. sex, clinical symptoms, location of tumor, diagnostic procedures before treatment, treatment and its complications and the 3- year survival. The factors influencing the survival were analyzed.
RESULTS: M/F was 16/24 with mean age 34.4 years. Their most common symptoms were coughing (90%). The left main bronchus was the most common site of involvement (25%). 95% of all cases underwent surgery and 5% because distant metastasis on admission underwent chemoradiotherapy without surgery. The most common surgical procedure was lobectomy (57.8%). Bronchial sleeve resection was performed on 10.4% of the patients. The most common pathology was the typical form (90%) and 5% of the madiastinal lymph nodes were involve. Carcinoid syndrome was seen in one patient (2.5%) and post operative adjuvant treatment were done in 5% of patients after surgery because mediastinal lymph node involvement. Post- operative recurrence of the tumor occurred in one patient (2.6%) of the atypical form with mediastinal lymph nodes involvement. The most common complication of surgery was a long- term air leakage after operation (10.4%) and the surgical death rate was 0%.3- Year survival was 92.5%. The factors mostly influencing the survival included the pathological type, early distant metastasis and mediastinal lymph node involvement.
CONCLUSION: Carcinoid tumors have mostly been responsive to surgical intervention, resulting in a long term survival. Postoperative adjuvant therapy is only required in cases with distant metastasis or in lymphatic involvement with an atypical pathological type.
CLINICAL IMPLICATIONS: Carcinoid tumors have mostly been responsive to surgical intervention, resulting in a long term survival.
DISCLOSURE: Reza Bagheri, No Financial Disclosure Information; No Product/Research Disclosure Information