PURPOSE: The purpose of this study is to assess the prevalence and clinical backgrounds of sleep apnea (SA) diagnosed by ambulatory nocturnal pulse oxymeter in outpatients of general cardiology in Japan.
METHODS: Subjects were consecutive 236 outpatients examined with ambulatory nocturnal pulse oxymeter and divided into 151 of control group (oxygen desaturation index; ODI 4%<5; C), 61 of mild SA group (5≤;ODI 4%<15; SA 1) and 24 of moderate to severe SA (15≤;ODI 4%; SA 2). The findings of demography, blood pressure (BP), 24-hour BP, blood examination, blood gas examination, respiratory function, Epworth sleepiness scale, systemic activity scale, electrocardiogram, chest rentogenogram, and echo-Doppler cardiography were compared in 3 groups.
RESULTS: Body mass indexes (BMI) were significantly larger in SA 1 (26.3) and SA 2 (30.3) than C (24.7). The occasional and morning diastolic BPs (mmHg) in SA 2 (87;95) were higher than C (78;82). Plasma glucose levels (mg/dL) were higher in SA 1 (132) and SA 2 (131) than C( 117). Triglycerides (mg/dL) and hematocrits (%) in SA 2 (197;44) were higher than those in C (149;41). The PCO2 (mmHg) in SA 2 (41) was higher than C (36), and PO2 (mmHg) and SaO2 (%) in SA 2 (82;96) were lower than C (93;97), respectively. No significant difference was seen in other indexes.
CONCLUSION: These results suggest that the patients with SA in general cardiology outpatients clinic in Japan have obesity, high plasma glucose and triglceride, high diastolic BP, especially early in the morning, polycytemia and hypoxia, those were compatible with metabolic syndrome, compared with control subjects without SA.
CLINICAL IMPLICATIONS: The prevalence of SA in outpatients of general cardiology in Japan is 36%, and patients with metabolic syndrome should be examined the presence of SA.
DISCLOSURE: Hitoshi Koito, No Financial Disclosure Information; No Product/Research Disclosure Information