0
Abstract: Poster Presentations |

CATHELICIDIN ANTIMICROBIAL PEPTIDE (CAMP) AND ITS EXPRESSION IN THE CONTEXT OF CLINICAL SEPSIS FREE TO VIEW

Dani Hackner, MD*; Sam Torbati, MD; Niels Borregaard, MD; Adrian Gombart, PhD
Author and Funding Information

Cedars Sinai, Los Angeles, CA


Chest


Chest. 2008;134(4_MeetingAbstracts):p68002. doi:10.1378/chest.134.4_MeetingAbstracts.p68002
Text Size: A A A
Published online

Abstract

PURPOSE: Sepsis constitutes a significant public health problem and the mechanisms that regulate the inflammatory response are incompletely understood. Endogenous human peptides have been reported to modulate the response to bacterial infection in sepsis, independent of known mechanisms of antibiotic resistance. We sought to investigate the role of Cathelicidin Anti-Microbial Peptide (CAMP) and its expression in clinical sepsis.

METHODS: During two weeks in August 2007, 15 sepsis patients admitted consecutively to the intensive care unit were identified and confirmed by two physicians. Serum from 12 was obtained prior to treatment and ELISA was performed on each sample for CAMP. Cases were divided into high and low CAMP levels by median. Demographics, severity, acuity, length of stay (LOS), ICU length of stay, and in-hospital mortality were obtained.

RESULTS: CAMP levels were 1482 +/− 289 (S.D.) for the high group and 712 +/− 263 (S.D.) for low group. 24 hour APACHE scores were 19 +/− 7 and 23 +/− 14 for the groups for the high and low groups, respectively. Acuity scores (QTISS and CLASSACT) were comparable. Mean ages were 74 +/−16 and 64 +/− 15, respectively. The high group had lower percentages of African Americans (17% versus 33%) and ethnic hispanics (0% versus 33%). Average length of stay was 9 +/− 4 for the high group and 25 +/− 18 for the low group (p=.07), and ICU LOS was 3.6 +/− 1.6 and 10.4 +/− 7.3 respectively, for patients who survived (p=.05). 3/6 patients in the low group died or went to hospice and none in the high group. Ejection fractions, rates of diastolic dysfunction, estimated filling pressures, and organisms identified were similar.

CONCLUSION: In very preliminary analysis, low CAMP levels appear to be associated with poor outcomes in sepsis, despite similar severity, acuity, and organism types. Further investigation is warranted to look at factors implicated in outcomes and levels of CAMP.

CLINICAL IMPLICATIONS: Further work is warranted on endogenous mediators of responses to sepsis and biomarkers of poor outcome in sepsis.

DISCLOSURE: Dani Hackner, No Financial Disclosure Information; Product/procedure/technique that is considered research and is NOT yet approved for any purpose. Cathelicidin assays are not approved for clinical applications at this time. This is basic research into the levels of bacterial killing proteins in clinical sepsis.

Tuesday, October 28, 2008

1:00 PM - 2:15 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543