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Abstract: Poster Presentations |

BIOMARKER FOR STAGING THE HOST IMMUNE RESPONSE IN SEPSIS FREE TO VIEW

Kevin Lawrence, MD*; Patrick White, MD; Gerald Morris, MD; Jody Jennemann, BS; Marin H. Kollef, MD
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Washington University School of Medicine, St. Louis, MO


Chest


Chest. 2008;134(4_MeetingAbstracts):p68001. doi:10.1378/chest.134.4_MeetingAbstracts.p68001
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Abstract

PURPOSE: Sepsis is associated with alterations in host immune function. Currently, those suffering from sepsis are classified according to a clinical phenotype with little or no knowledge of their immune status. We hypothesize that measured immune function will correlate with clinical outcomes.

METHODS: A biomarker that detects cell mediated immunity (CMI) by measuring the concentration of adenosine triphosphate (ATP) released from CD4+ T cells following mitogen stimulation was prospectively evaluated in 30 patients admitted with sepsis to an ICU.

RESULTS: Patients with sepsis (n=30) have significantly higher mean amounts of ATP in their nonstimulated CD4+ T cells compared to healthy controls (n=35), 32 ng/mL and 12 ng/mL, respectively (p<0.05). Patients with sepsis have significantly lower mean amounts of ATP in their stimulated CD4+ T cells than healthy controls, 377 ng/mL and 471 ng/mL, respectively (p<0.05). Survivors of sepsis (n=22) have significantly higher mean amounts of ATP in their stimulated CD4+ T cells than nonsurvivors of sepsis (n=8), 433 ng/mL and 223 ng/mL, respectively (p<0.05).

CONCLUSION: Low levels of cell mediated immune function are associated with mortality in patients with sepsis.

CLINICAL IMPLICATIONS: Recognition of an immunological phenotype in patients with sepsis may provide improved early risk stratification.

DISCLOSURE: Kevin Lawrence, Other This study was supported by Cylex Inc. which owns the patented Immuknow technology.; No Product/Research Disclosure Information

Tuesday, October 28, 2008

1:00 PM - 2:15 PM


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