PURPOSE: Sarcoidosis is a multisystem granulomatous disorder of unknown origin characterized by activation of T lymphocytes and mononuclear phagocytes at sites of disease. Although the frequency and clinical presentations of sarcoidosis vary among geographic regions, sarcoidosis in Asian has been known rare. In this study, we assesed clinical manifestations and prognosis of biopsy confirmed sarcoidosis patients in Korea.
METHODS: A single tertiary university hospital retrospective review was conducted of all tissue confirmed sarcoidosis patients between January 1995 and August 2007. Patient characteristics, symptoms, duration of disease, involved organs, methods of pathologic diagnosis, complications, recurrence, and responsiveness to treatment were collected.
RESULTS: 103 patients were enrolled. Interval from onset of symptoms to hospitalization was 7.9 months. Median follow-up duration was 42 months. 30.1% (31/103) of patients were asymptomatic and most common symptom was cough or sputum (24.3%). Lung involvement was 94.2%, skin involvement 26.2% (erythema nodosum 7.8%) and there was no patient with heart or renal involvement. 51.5% of patients showed bilateral hilar lymphadenopathy and pulmonary infiltration and 6.8% presented with normal chest radiograph. Most of patients (74.1%) showed normal pulmonary function. 55.6% of patients showed elevated angiotensin-converting enzyme and hypercalcemia was noted in 1.9%. Pathologic diagnosis was made by mediastinoscopic biopsy (42.7%), transbronchial lung biopsy (21.4%) and VATS (5.8%). 67 patients were treated with systemic steroid: 65.7% were improved, and 22.4% were relapse after stopping steroid treatment. Clinical courses were stable or resolved spontaneously without treatment in most of patients (75.9%). Overall clinical outcome of patients were: improved (74%), stable (19%) and unfavorable (7%).
CONCLUSION: Clinical manifestations were similar with those in non-Asian populations. The long-term clinical courses of sarcoidosis patients in Korea were relatively favorable.
CLINICAL IMPLICATIONS: Sarcoidosis is rare in Korea, but clinical presentations and treatment courses are very similar with those in non-Asian populations.
DISCLOSURE: Hee-Joung Kim, No Financial Disclosure Information; No Product/Research Disclosure Information