PURPOSE: t has been said that childhood infections shift the immunological balance from TH2 (predominantly responsible for allergies) to TH1(responsible for immunity against infections).BCG given at birth is also an type of infection with a live attenuated form of mycobacterium bovis. This study was planned to see whether administration of BCG effects incidence of asthma in children.
METHODS: The study has been conducted between the period 1st April 2005 to 31st March, 2006 in the school going children of the age group 5–15 years of rural and urban areas of Ajmer district. The total sample was 6,959. Asthma by using a validated questionnaire, clinical examination,by spirometery and bronchodilator reversibility test. Evidence of BCG was seen by noting the scar mark on arm.
RESULTS: In urban areas 4416 (96.9%) children were vaccinated for BCG as seen by scar mark on arm. Out of these 197 were asthmatic (4.46%). The number of children, non-vaccinated was 137 (3.1%), out of which 5 were found to have asthma(5/137=3.6%). In rural areas 2150 (88.9%) children were vaccinated for BCG as seen by scar mark on arm. Out of these 72 were asthmatic (3.34%). The number of children, non-vaccinated was 266 (11%), out of which 11 were found to have asthma (11/266= 4.1%).
CONCLUSION: In urban and rural areas the rates of prevalence of asthma in children vaccinated for BCG were 4.46% and 3.34% respectively. In children not vaccinated, the rate of prevalence of asthma was 3.6% in urban children and 4.1% in rural children. Statistically p was >.05.
CLINICAL IMPLICATIONS: In the present study status of BCG vaccination did not effect the prevalence of asthma in both urban & rural area.
DISCLOSURE: Sidharth Sharma, None.