PURPOSE: Lung cancer became the leading cause of death from malignancy among female population worldwide. Analysis of changes in histological type and age in female patients with lung cancer in the last 20 years.
METHODS: Obtained preoperativ and operative tissue specimens were analyzed. Histological lung cancer classification was applied, with three major histological types, squamous cell carcinoma (SCC), adenocarcinoma (AC) and small cell lung cancer (SCLC), and the fourth group with rare lung tumors. The age groups were divided in decades, except the first one including the age up to 30 years. The data were analyzed by the Chi-Square Test (χ2) with level of significance set at p < 0.05.
RESULTS: Bioptic tissue specimens were analyzed in 1042 females. SCC was most frequently diagnosed (45.7%). The most frequent lung cancer in women was diagnosed between 61 to 70 years of age –368 (35.3%) cases. SCC was the most frequently diagnosed cancer in all age groups, and mainly between 61 do 70 –180 (38.1%), and AC 103(35.0%), respectively. SCLC was mostly diagnosed in younger age –51–60 years - 104 (44.8%). Other rare tumors were mostly diagnosed in younger patients. In 170 females, lung cancer diagnosis was verified by analysis of surgical specimens. The incidence of SCC and AC was almost equal - 76 (44.7% ) and 68 (40.6%), respectively. AC was most frequently diagnosed in 2000, in 19 (57.6%) cases. SCC was most frequently diagnosed in other investigated years. There was no statistical significance between these data, p=0.105. Most frequently operated women were between 51 and 60 years of age, 60 (35.3%) patients, p=0.277.
CONCLUSION: The fact one should always be aware of in lung cancer diagnosis and treatment of these women is different distribution of histological types, prognosis and therapeutic response to specific medicaments in comparison with male patients.
CLINICAL IMPLICATIONS: Lung cancer treatment and therapeutical response to certain drugs in women is patially different from those in men as well as risk factors, prognosis and distribution of histological type.
DISCLOSURE: Jelena Stojsic, None.