PURPOSE: We investigated risk factors for ischemic stroke in patients with diabetes mellitus.
METHODS: We investigated in 408 diabetics, mean age 66 years (47% women), with ischemic stroke and in 404 age-and sex-matched diabetics without ischemic stroke risk factors for stroke.
RESULTS: The prevalence of race, hypertension, smoking, obesity, prior stroke, atrial fibrillation, carotid arterial disease, and prosthetic valve was similar between diabetics with and without stroke. A hemoglobin A1c level <7.0% was present in 141 of 408 diabetics (35%) with ischemic stroke and in 221 of 404 diabetics (55%) without ischemic stroke (p<0.001). A serum low-density lipoprotein (LDL) cholesterol <100 mg/dl was present in 164 of 408 diabetics (40%) with ischemic stroke and in 269 of 404 diabetics (67%) without ischemic stroke (p<0.001). A serum LDL cholesterol <70 mg/dl was present in 34 of 408 diabetics (8%) with ischemic stroke and in 127 of 404 diabetics (31%) without ischemic stroke (p<0.001).
CONCLUSION: Diabetics with a hemoglobin A1c level of 7.0% or higher and a serum LDL cholesterol of 100 mg/dl or higher have a higher prevalence of ischemic stroke than diabetics with lower hemoglobin A1c and serum LDL cholesterol levels.
CLINICAL IMPLICATIONS: Patients with diabetes mellitus should have their hemoglobin A1c reduced to <7.0% and their serum LDL cholesterol reduced to <70 mg/dl.
DISCLOSURE: Gautham Ravipati, No Financial Disclosure Information; No Product/Research Disclosure Information