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Abstract: Poster Presentations |

PATIENTS WITH ISCHEMIC STROKE, INTRACRANIAL HEMORRHAGE, AND SUBARACHNOID HEMORRHAGE WITH INCREASED SERUM TROPONIN I LEVELS HAVE AN INCREASED IN-HOSPITAL MORTALITY FREE TO VIEW

Rasham Sandhu, MD*; Wilbert S. Aronow, MD; Archana Rajdev, MD; Rishi Sukhija, MD; Harshad Amin, MD; Amandeep Sangha, MD
Author and Funding Information

New York Medical College, Valhalla, NY


Chest


Chest. 2008;134(4_MeetingAbstracts):p42004. doi:10.1378/chest.134.4_MeetingAbstracts.p42004
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Abstract

PURPOSE: To investigate in patients with ischemic stroke, intracranial hemorrhage, and subarachnoid hemorrhage the association of increased serum troponin I levels with in-hospital mortality.

METHODS: The patients included 175, mean age 67 years, with ischemic stroke, 107, mean age 61 years, with intracranial hemorrhage, and 96, mean age 51 years, with subarachnoid hemorrhage. All diagnoses were made by a neurologist and confirmed by magnetic resonance imaging or brain computed tomography. Troponin I levels were drawn within 24 hours of stroke in 161 of 175 patients (92%) with ischemic stroke, in 94 of 107 patients (88%) with intracranial hemorrhage, and in 96 of 96 patients (100%) with subarachnoid hemorrhage. A troponin I level >0.4 ng/ml was considered increased.

RESULTS: In patients with ischemic stroke, in-hospital mortality occurred in 15 of 23 patients (65%) with increased troponin I versus 6 of 138 patients (4%) with normal troponin I (p< 0.001). In patients with intracranial hemorrhage, in-hospital mortality occurred in 9 of 14 patients (64%) with increased troponin I versus 22 of 80 patients (28%) with normal troponin I (p <0.005). In patients with subarachnoid hemorrhage, in-hospital mortality occurred in 8 of 20 patients (40%) with increased serum troponin I versus 8 of 76 patients (11%) with normal serum troponin (p<0.005).

CONCLUSION: Patients with ischemic stroke, intracranial hemorrhage, and subarachnoid hemorrhage with elevated serum troponin levels within 24 hours of stroke have an increased in-hospital mortality.

CLINICAL IMPLICATIONS: Patients with ischemic stroke, intracranial hemorrhage, and subarachnoid hemorrhage with elevated serum troponin levels within 24 hours of stroke have an increased in-hospital mortality.

DISCLOSURE: Rasham Sandhu, No Financial Disclosure Information; No Product/Research Disclosure Information

Tuesday, October 28, 2008

1:00 PM - 2:15 PM


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