PURPOSE: The relationship between aortic stenosis (AS) and cardiovascular risk factors has not been well delineated. We hypothesized that severe AS in elderly patients is related to cardiovascular risk factors.
METHODS: We retrospectively studied 48 consecutive patients with AS and age> 60 years old (male 25, female 23, age 74.6± 12.3 years). Twenty-five patients had aortic valve area (AVA) ≤; 1cm2 (included AVA≤; 0.75cm2 13 patients, AVA> 0.75cm2 and ≤; 1cm2 12 patients) and 23 patients with AVA> 1cm2 confirmed by echocardiography at the last follow-up. Cardiovascular risk factors at time of initial diagnosis of AS included coronary artery disease (CAD), hypertension (HTN), diabetes mellitus (DM), hyperlipidemia (abnormal in total cholesterol and/or triglycerides and/or LDL cholesterol) and smoking. AVA data was collected from final echocardiogram over 2 year follow-up or before end point of all cause mortality or aortic valve replacement (AVR).
RESULTS: The incidence of coronary artery disease, hypertension, diabetes mellitus, hyperlipidemia and smoking were 48%, 83%, 38%, 58% and 19%, respectively. Twenty-three patients had AVR and 3 patients died during follow-up. After adjustment for gender and age by logistic regression analysis, AVA≤; 1cm2 was associated with higher incidence of hyperlipidemia (p= 0.003) (Table).
CONCLUSION: In elderly patients, severe AS is associated with a higher incidence of hyperlipidemia at time of initial diagnosis of AS. Whether hyperlipidemia is an independent predictive factor of severe AS in elderly patients requires further investigation.
CLINICAL IMPLICATIONS: The hyperlipidemia maybe an independent predictive factor of severe AS.
DISCLOSURE: Suman Pasupuleti, None.