PURPOSE: Deep Venous Thrombosis (DVT) is a multi factorial disease in which acquired and genetic causes are involved. Statins, in addition to their lipid lowering effect, have many antithrombotic effects and were shown in multiple trials to decrease the risk of cardiovascular events. The objective of this study is to evaluate the influence of statins use on the recurrence rate in patients with DVT.
METHODS: We retrospectively reviewed the medical records of 299 hospitalized patients for documented DVT from 2005 to 2007. 64 patients were taking statins and 235 were not. Recurrence rate was analyzed among the two groups.
RESULTS: Of all patients, 235 (78.6%) were not taking statins (114 males, 121 females, age range 18 to 94 years, mean age 60.4 years) and 64 (21.4%) were on statins (29 males, 35 females, age range 36 to 88 years, mean age 68.6 years). In the group not taking statins, 74 (31%) patients had recurrent DVT and 161 (69%) didn’t. In the group taking statins, 12 (19 %) patients had recurrent DVT and 52 (81%) didn’t. None of these associations was statistically significant (P = 0.061).
CONCLUSION: DVT recurrence rate among patients not receiving statins was higher than the patients receiving statins, but we were not able to detect significant association. This possible protective effect of statins warrants further investigations in a larger sample.
CLINICAL IMPLICATIONS: In addition to its cardiovascular protective effect, statins might have a role in modulating the clinical outcome and recurrence rate in patients with DVT.
DISCLOSURE: Ashraf Rashid, None.