PURPOSE: Statins are increasingly reported in the literature with beneficial effects in a variety of patient groups due to its anti-inflammatory and immunomodulatory therapeutic roles. Our aim is to assess the association between statin administration and mortality in critical ill patient.
METHODS: In a retrospective cohort analysis, all patients admitted to the intensive care unit (ICU) between January 1, 2007 and December 31, 2007 were divided into two groups based on the status of outpatient treatment with statin medication. The statin group is where patients received consistent statin therapy for one year prior to ICU admission and the control group is where patients did not have statin therapy.
RESULTS: Total of 1382 patients were admitted to ICU in 2007. 194 patients in the statin group with average day 1 APACHE II of 17.6 and 1188 patients in the control group with average APACHE II of 17.5. ICU mortality rate for statin group was 10% compared to 12% for the control group (p< 0.05). There was no statistical difference in hospital mortality rate (20% for control versus 21% for statin). The apparent mortality benefit persisted after controlling for differences in age and gender.
CONCLUSION: This retrospective study demonstrates a survival benefit associated in the group of patients that were on statin therapy prior to ICU admission. The potential protective effects of this observation warrant further investigation.
CLINICAL IMPLICATIONS: In this Analysis, the use of statins might have a protective effect on patients by reducing mortality compared to patients not receiving statins. These data will be used to develop a more systmatic evaluation of statin use in patients with sepsis.
DISCLOSURE: Mouhamad Jamil, No Financial Disclosure Information; No Product/Research Disclosure Information