PURPOSE: To investigate the association of increased cardiac troponin I levels with in-hospital mortality and valve replacement in patients with infective endocarditis.
METHODS: The 62 patients included 36 men and 26 women, mean age 60 ± 9 years, with infective endocarditis diagnosed by the Duke criteria. All 62 patients had blood drawn for measurement of cardiac troponin I levels. A cardiac troponin I level >0.4 ng/ml was considered increased. All 62 patients underwent transesophageal echocardiography.Student's t tests were used to analyze continuous variables. Chi-square tests were used to analyze dichotomous variables.
RESULTS: Transesophageal echocardiography diagnosed valvular vegetations in 56 of the 62 patients (90%). Cardiac troponin I levels were increased in 35 of the 62 patients (57%). In-hospital mortality or valve replacement occurred in 18 of 35 patients (51%) with increased cardiac troponin I levels versus 4 of 27 patients (15%) with normal cardiac troponin I levels (p<0.005).
CONCLUSION: In conclusion, patients with infective endocarditis and increased cardiac troponin I levels have a higher incidence of in-hospital mortality or valve replacement than those with normal cardiac troponin I levels.
CLINICAL IMPLICATIONS: Patients with infective endocarditis and increased cardiac troponin I levels are at high risk for in-hospital mortality or valve replacement.
DISCLOSURE: Peter Tsenovoy, No Financial Disclosure Information; No Product/Research Disclosure Information