PURPOSE: COPD exacerbation is a common cause of mortality, morbidity, and hospital admissions. FEV (1) and age have been considered the most important mortality predictors in COPD.Both increased Airway Resistance (Raw) and Carbon Monoxide Diffusing Capacity (DLCO) can be used as supplemental data confirming obstruction in COPD patients. So far, there have been no studies to look at the value of using Raw or DLCO to predict the need for admission in COPD patients.
METHODS: This is a retrospective observational study of hospital admissions for a cohort of COPD patients (N= 237) over a one- year period. Airway Resistance (Raw) and Carbon Monoxide Diffusing Capacity (DLCO) were measured at the start of the observational period and used to predict outcome. The outcome was the need for admission (0 admissions vs. ≥ 1 admission). Cutoffs were established by Receiver Operating Characteristics (ROC) curve analysis.
RESULTS: Cutoffs for Raw and DLCO were 292 cm H2O/L/sec and 65mL/mmHg/min, respectively. At these values, the percentage of patients requiring admission, odds ratio (95% CI) and p-value were 17.7%, 0.03(0.01–0.06), p< 0.0001 for Raw and 72.5%, 4.75(2.51- 9.12), p< 0.0001 for DLCO.
CONCLUSION: The results of our study show that there was a strong association between increased Raw or decreased DLCO and the number of hospital admissions in COPD patients.
CLINICAL IMPLICATIONS: This study suggests that the need for hospital admission in COPD patients can be predicted by increased Raw or decreased DLCO.
DISCLOSURE: Mahmoud Moammar, No Financial Disclosure Information; No Product/Research Disclosure Information