PURPOSE: In the stent era, lesion length remains an important predictor for restenosis. Drug-eluting stents (DESs) have significantly reduced in-stent restenosis (ISR), but results in long lesions are still lacking. Therefore we investigated Impact of DES on the outcome of patients with diffuse coronary lesion.
METHODS: Between January 2004 and January 2005, 80 patients (94 lesions) with > 20 mm in lesion length who were treated with one or more DES and underwent follow-up coronary angiogram were selected for this study. The patients were divided into group 1 for those who had 21 to 35 mm in lesion length, group 2 with 36 to 50 mm in lesion length, and group 3 with ≥ 51 mm in lesion length.
RESULTS: Mean clinical follow-up duration was 9 months. At 6 months follow-up angiogram, 6.4% of lesions had binary ISR (5.0% group 1, 8.7% group 2 and 9.1% group 3). Percent diameter stenosis was 6.0±18.15% in group 1, 12.61±21.99% in group 2, and 19.81±31.26% in group 3(p<0.05). Late lumen loss was 0.17±0.50 mm in group 1, 0.39±0.66 mm in group 2, and 0.59±0.93 mm in group 3 (p<0.05). Lesion length was associated with increases in percent diameter stenosis and late lumen loss (per 15 mm of 6.9% and 0.21 mm).
CONCLUSION: DESs implantation is considered safe and effective in the treatment of diffuse lesion. However, lesion length may be associated with increases in percent diameter stenosis and late lumen loss at 6 months follow-up.
CLINICAL IMPLICATIONS: DESs implantation is considered safe and effective in the treatment of diffuse lesion.
DISCLOSURE: Hyeon Gook Lee, No Financial Disclosure Information; No Product/Research Disclosure Information