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Abstract: Poster Presentations |

INCIDENCE OF MORTALITY IN 1,040 PATIENTS WITH CARDIOVASCULAR DISEASE WITH NORMAL AND ABNORMAL QRS DURATION AND WITH NORMAL AND ABNORMAL LEFT VENTRICULAR EJECTION FRACTION FREE TO VIEW

Hoang M. Lai, MD*; Wilbert S. Aronow, MD; Archana Rajdev, MD; Amit Asija, MD; Khanh V. Lai, MD; Jerry George, DO; John A. McClung, MD
Author and Funding Information

New York Medical College, Valhalla, NY


Chest


Chest. 2008;134(4_MeetingAbstracts):p2001. doi:10.1378/chest.134.4_MeetingAbstracts.p2001
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Abstract

PURPOSE: The incidence of mortality in patients with cardiovascular disease with a normal QRS duration on the resting electrocardiogram (ECG) and a normal left ventricular ejection fraction (LVEF), a normal QRS duration and an abnormal LVEF, an abnormal QRS duration and a normal LVEF, and an abnormal QRS duration and an abnormal LVEF needed to be investigated.

METHODS: The QRS duration on the resting ECG and LVEF determined by 2-dimensional echocardiography were measured in 1,040 patients with cardiovascular disease. A QRS duration of ≥120 msec was considered abnormal. A LVEF <50% was considered abnormal. The 1,040 patients included 627 men and 413 women, mean age 66 ± 15 years. All-cause-mortality was determined at follow-up. Mean follow-up was 497 days ± 311 days.

RESULTS: Death occurred in 65 of 598 patients (11%) with a normal QRS duration and a normal LVEF, 1 in 19 of 100 patients (19%) with a normal QRS duration and an abnormal LVEF, 2 in 53 of 242 patients (22%) with an abnormal QRS duration and a normal LVEF, 3 and in 36 of 100 patients (36%) with an abnormal QRS duration and an abnormal LVEF 4 (p <0.025 comparing 1 with 2; p <0.001 comparing 1 with 3 and 1 with 4; p <0.01 comparing 2 with 4 and 3 with 4).

CONCLUSION: Patients with cardiovascular disease with an abnormal QRS duration and an abnormal LVEF have the highest mortality. Patients with cardiovascular disease with a normal QRS duration and a normal LVEF have the lowest mortality.

CLINICAL IMPLICATIONS: Patients with cardiovascular disease and an abnormal LVEF and an abnormal QRS duration had a significant 3.3 times higher mortality than patients with cardiovascular disease and a normal LVEF and a normal QRS duration.

DISCLOSURE: Hoang Lai, None.

Tuesday, October 28, 2008

1:00 PM - 2:15 PM


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