PURPOSE: The typical creatine kinase (CK) isoenzymes include CK-BB, CK-MB and CK-MM. Macro CK type 1, one of the atypical CK enzymes, has been identified in human serum, but the clinical significance still remains uncertain.
METHODS: In our laboratory, 105 patients who expressed serum macro CK isoenzyme type 1 were identified from March 2004 to March 2007. We found that macro CK type 1 recurred after at least one month in 16 patients.
RESULTS: Clinical diagnoses were myopathy in 14 patients, one sepsis and one had acute coronary syndrome. The averages of serum total CK and macro CK type 1 were 9,132 and 1,925 (U/L), respectively. The linear regression analysis between recurrent macro CK type 1 and total CK revealed a good correlation (y = 3.5054x + 2381.3, R2 = 0.7822, P<0.001). Three patients had critical illness, including one respiratory failure and two mortalities. Good linear correlation is documented between total CK and recurrent macro CK type 1.
CONCLUSION: In conclusion, the macro CK type I isoenzyme recurred primarily in patients with myopathy.
CLINICAL IMPLICATIONS: In conclusion, good linear correlation between total CK and recurrent macro CK type 1 was demonstrated by our study, and macro CK type 1 possibly reflects the degree of cell damage or disease activities. We also found that recurrent macro CK type I isoenzyme is primarily associated with myopathy.
DISCLOSURE: Pao-Hsien Chu, No Financial Disclosure Information; No Product/Research Disclosure Information