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Abstract: Poster Presentations |

EFFECT OF SLEEP FRAGMENTATION ON LIPID PROFILE IN NORMAL AND OVERWEIGHT SUBJECTS FREE TO VIEW

Rachel J. Givelber, MD*; Jigme M. Sethi, MD; Lynnette Robinson, BS; Yingze Zhang, PhD; Christopher P. O'Donnell, PhD; John Zeiner, BS; Augustine M. Choi, MD; Mark H. Sanders, MD
Author and Funding Information

University of Pittsburgh School of Medicine, Pittsburgh, PA


Chest


Chest. 2007;132(4_MeetingAbstracts):653. doi:10.1378/chest.132.4_MeetingAbstracts.653
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Abstract

PURPOSE: Obstructive Sleep Apnea-Hypopnea (OSAH), characterized by sleep fragmentation and cyclic hypoxia is linked to features of the Metabolic Syndrome. A specific contribution of sleep fragmentation to altered lipid profile has not been explored.

METHODS: 10 normal (GROUP 1: age: 29.6 ± 12.8; BMI: 22.2 ± 2.1) and 12 overweight (GROUP 2: age: 25.1 ± 9.3; BMI: 28.8 ± 4) subjects without Metabolic Syndrome or OSAH underwent a 4-Night/3-Day protocol. NIGHT (N)1 Polysomnography: acclimatization/OSAH screening; N2: baseline data; N3 and N4: induced sleep fragmentation. Blood was sampled for Total Cholesterol (CHOL-T), LDL-C, HDL-C, triglycerides (TRIG) after N2 and N4. Differences within and between groups were assessed with Wilcoxon signed-rank and Mann Whitney tests. Data are mean ± SD.

RESULTS: For GROUPS 1 vs. 2: AROUSAL INDEX - N2: 7.59 ± 2.33 vs. 9.21 ± 4.36 (p=ns); average N3-4: 25.08 ± 3.26 vs. 27.99 ± 4.67 (p=ns); TOTAL SLEEP TIME (TST) - N2: 437.9 ± 62.32 min. vs. 417.31 ± 70.56 min. (p=ns); average N3-4: 401.82 ± 48.86 min vs. 390.46 ± 68.95 min. (p=ns). The average TST was lower over N3-4 than on N2 in GROUP 1 (p=0.009) but not different in GROUP 2 (p=0.071). In GROUP 1, after N2 vs. N4- CHOL-T: 167.3 ± 27.4 vs. 170.8 ± 30.4, (p=ns); LDL-C: 85.9 ± 27.6 vs. 90.3 ± 27.3 (p=ns); HDL-C: 54.7 ± 11.3 vs. 53.8 ± 12.6 (p=ns); TRIG: 133.9 ± 56.4 vs. 134.3 ± 52.8 (p=ns). In GROUP 2, after N2 vs. N4- CHOL-T: 177.8 ± 52.4 vs. 166.8 ± 55.5 (p=0.027); LDL-C: 109.5 ± 40.1 vs. 93.6 ± 47.1 (p=ns); HDL-C: 45 ± 13.6 vs. 41.8 ± 13 (p=0.005); TRIG: 124.7 ± 65.6 vs. 132.7 ± 59.5 (p=ns). Baseline lipid values did not differ between Groups 1 and 2.

CONCLUSION: Moderate sleep fragmentation is associated with reduced HDL-C and CHOL-T in overweight but not in normal weight individuals without Metabolic Syndrome.

CLINICAL IMPLICATIONS: Sleep fragmentation has a differential effect on lipid profile in overweight and normal weight individuals.

DISCLOSURE: Rachel Givelber, No Product/Research Disclosure Information; Consultant fee, speaker bureau, advisory committee, etc. MH Sanders has been on an advisory panel for Sanofi-Aventis and is a consultant to Respironics Inc.

Wednesday, October 24, 2007

12:30 PM - 2:00 PM


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