PURPOSE: To evaluate the effect of uvulopalatopharyngoplasty (UPPP) on serum level of nitric oxide derivatives (NOx) in obstructive sleep apnea syndrome (OSAS).
METHODS: Ten healthy subjects and 20 subjects with OSAS who desired UPPP were prospectively enrolled. All underwent measurement of serum levels of NOx from peripheral blood samples as well as a sleep study. These studies were repeated 3 months after UPPP in patients with OSAS.
RESULTS: Serum level of NOx in OSAS patients before UPPP was lower when compared with normal subjects (14.2 ± 5.7 v.s. 30.8 ± 7.6 μM). After UPPP, the NOx remained reduced in those whose OSAS did not respond to surgery (group IIb, n = 12) (14.8 ± 6.4 v.s. 14.9 ± 5.6 μM), while it returned to normal level in patients whose OSAS improved after UPPP (group IIa, n = 8) (13.2 ± 5.4 v.s. 29.3 ± 6.3 μM).
CONCLUSION: In conclusion, reduced serum NOx in patients with OSAS returns to normal if UPPP results in amelioration of OSAS.
CLINICAL IMPLICATIONS: Reduced serum NOx in patients with OSAS will return to normal with effective UPPP therapy which is congenial to CPAP treatment, and to determine serum NOx level return to normal or not depend primarily on effectiveness of treatment.
DISCLOSURE: Ching-Chi Lin, No Financial Disclosure Information; No Product/Research Disclosure Information