PURPOSE: In this study, we investigated the relationships of apnea hypopnea index (AHI) and body mass index (BMI) to premature ventricular arrhythmias (PVC) among patients with obstructive sleep apnea (OSA). We also examined whether continuous positive airway pressure has a positive effect on PVC.
METHODS: We conducted a prospective study of patients who were evaluated for OSA at the Kings County Hospital Sleep Clinic. Polysomnographic data were obtained both at baseline and during OSA treatment with Continuous Positive Airway Pressure. The present analysis of PVC's focused on EKG recordings that were analyzed by a trained investigator. We looked at patients with severe OSA who had an AHI ≥ 30 and analyzed there EKG's. Patients with PVC of 10 or more per hr were considered at risk and included in the analysis.
RESULTS: 154 patients with a mean age (± SD) of 46.27 ± 12.54 yrs were included in the study. 72% were Black; 3% White; 22% Hispanic; and 3% other ethnicities. 44% of the patients were females, and 52% were males. Overall, 46% of the patients were diagnosed with Severe OSA; their average BMI (± SD) was 43.90 ± 9.90. Of the OSA patients, 8% had PVC's ≥ 10. Pearson correlation analyses revealed no significant relationships of AHI and BMI to PVC [r = -.12, r = -.04, respectively]. Using repeated-measures ANOVA, we found a significant reduction in both AHI (± SD) [77 ± 10 vs. 13 ± 5; F = 45, P < 0.0001] and PVC (± SD) [77 ± 10 vs. 13 ± 5; F = 45, P < 0.0001] subsequent to CPAP treatment.
CONCLUSION: BMI and AHI did not show a significant association with PVC, but administration of CPAP decreased the incidence of AHI and PVC. Reduction in PVC's might be due to the decrease in the transmural pressure.
CLINICAL IMPLICATIONS: CPAP therapy is an important approach in the management of ventricular arrhythmias in patients with severe OSA.
DISCLOSURE: Ali El Atat, No Financial Disclosure Information; No Product/Research Disclosure Information