PURPOSE: To reveal the prevalence and the severity of obstructive sleep apnea (OSA) in patients with refractory hypertension (RH) in a Tunisian population.
METHODS: prospective study carried out in 33 patients with RH and 30 patients with controlled hypertension (CH) followed in Djerba hospital. RH was defined as a clinic systolic blood pressure (BP) ≥ 140 and/or diastolic BP ≥ 90 mmHg despite the low sodium diet and the combination of 3 antihypertensive medications (AHM) at recommended doses including a diuretic. Patients with controlled hypertension (CH) received 1 ≤; AHM ≤; 3, had clinic BP < 140/90 mmHg and were matched to those with RH on age, sex and body mass index (BMI). Patients with known OSA were excluded. All subjects underwent overnight ventilation polygraphy to determine apnea-hypopnea index (AHI). The ones with AHI ≥ 10 events/hour were classified as having OSA.
RESULTS: OSA was significantly more frequent (prevalence = 75,7% versus 46,6%, p = 0,017) and AHI was significantly higher (29,9 events/hour versus 15,4 events/hour, p = 0,001) among patients with RH compared with those with CH.
CONCLUSION: Eight patients on ten with RH have OSA.
CLINICAL IMPLICATIONS: This justifies the systematic practice of ventilation polygraphy in patients with RH.
DISCLOSURE: Amine Dhouib, No Financial Disclosure Information; No Product/Research Disclosure Information