PURPOSE: Pneumocystis carinii is a common cause of pneumonia in immunocompromised patients. The level of serum lactate dehydrogenase (LDH) has been reported to be useful as a marker of Pneumocystis carinii pneumonia (PCP). The purpose of this study was to determine the utility of serum LDH as a marker of PCP among HIV patients, and also to determine if there is relationship between serum LDH levels and CD4+ lymphocyte count.
METHODS: Retrospective study comparing LDH values, CD4+ T-lymphocyte count, and length of hospital stay among 62 HIV patients admitted from 2004-2006 at St. Michael's Medical Center, Newark, New Jersey. Two sample t-test was used to determine difference between the LDH values of patient with PCP and those without PCP. Linear regression was used to determine relationship between LDH values and CD4 count.
RESULTS: All patients underwent bronchoscopy. 15 patents (24%) had a presumptive diagnosis of PCP using the Silver Stain. The mean value of pO2, total bilirubin, and LDH of PCP patients and non-PCP patients did not differ statistically. CD4+ T-lymphocyte count was significantly less in PCP patients. Nevertheless, Mean CD4+ T-lymphocyte count was less than 200 cells/mm3 blood in both PCP and non-PCP patients. Mean LDH level was higher in PCP group (342.3) compared with non-PCP group (304.8).
CONCLUSION: Serum LDH level has limited utility as a marker of PCP among HIV patients. There is no relationship between serum LDH levels and CD4+ lymphocyte count among HIV patients.
CLINICAL IMPLICATIONS: The utility of serum LDH as a marker of PCP among HIV patients.
DISCLOSURE: Roberto Santos, No Financial Disclosure Information; No Product/Research Disclosure Information