PURPOSE: Human Immunodeficiency virus (HIV) Infection constitutes a major risk factor for the development of tuberculosis infection. In Israel, a country of immigrants, the dispersion of tuberculosis and HIV is highly related to the immigrant 's origin country The purpose of this study is to describe the clinical, bacteriologic and epidemiologic characteristics of patients co infected with both tuberculosis and HIV.
METHODS: The patients included in this study were hospitalized in the pulmonary department of “Shmuel Harofe” hospital, from January 2000 to December 2006. They were located through a computer search in the hospital registry that identify all the patients with a diagnosis of HIV/AIDS and tuberculosis.
RESULTS: 1059 tuberculosis cases were hospitalized in our department between January 2000 and December 2006. 93 of them were co infected with tuberculosis and HIV.Most of the patients came from epidemic countries (61.2% from Ethiopia, 20.4% from former Soviet Union, none was born in Israel). Only 10% of the cases were resistant to the first line drugs and only 32% showed extra pulmonary involvement. The response rate to the treatment was high with a median hospitalization time of 70 days. The mortality rate was 3.2%.
CONCLUSION: Our patients showed a good short term outcome and a high prevalence of pulmonary disease. The sensibility of the mycobacterium to the first drugs line, rapid detection and expert center are good prognostic factor. These encouraging results are accounted for by the fact that tuberculosis patients in Israel are early identified and treated continuously by strictly observed therapy, thereby the development of drug resistance is low.
CLINICAL IMPLICATIONS: It is critical to diagnosis early tuberculosis in the setting of HIV infection, to hospitalize the patients in order to observe and control side effects of drugs and to continue on directed observed therapy.
DISCLOSURE: Daniele Bendayan, No Financial Disclosure Information; No Product/Research Disclosure Information