PURPOSE: South Korea is an intermediate tuberculosis-burden country. Although the control of active pulmonary tuberculosis is still remaining as main issue in community medicine, there are considerable needs for supportive management of symptomatic patients with post-tuberculosis destroyed lung(PTDL).
METHODS: We evaluated lung function, exercise tolerance and health-related quality of life (HRQoL) measurement with Korean version of St. George Respiratory Questionnaire (SGRQ) in 23 patients with parenchymal damage to more than 1/2 of one lung due to previous pulmonary tuberculosis. Patients were symptomatic and there was no active tuberculous disease.
RESULTS: In spirometry, obstructive pattern (FEV1/FVC less than 70%) was observed in 19 patients (82.6%, 19/22). Mean FEV1 and FVC of % predicted value were 47.3% and 61.1%, respectively. There were no significant differences in spirometric values between never smoker and ex-smoker with smoking history of more than 10 pack-years. At cardiopulmonary test, VO2 max and O2 pulse were markedly decrease; mean 39.0% and mean 61.3%, respectively. In quality of life measurement, impact score (mean 29.5) was significantly lower than symptom score (mean 52.1) and activity score (mean 51.9) (p<0.05, p<0.01). Cronbach's alpha coefficient value for reliability was more than 0.7 in each subscale. Among SGRQ subscales, symptom score showed greater correlation with objective values such as FEV1, FEV1/FVC and VO2max (p<0.05).
CONCLUSION: Most patients with PTDL showed obstructive pattern as well as restrictive pattern in spirometry data. Relablity and validity of SGRQ was acceptable for the measurement of HRQoL in patients with PTDL.
CLINICAL IMPLICATIONS: Chronic airflow obstruction should be considered as a main therapeutic target in the management of symptomatic patients with PTDL. SGRQ could be used for the measurement of HRQoL in patients with PTDL.
DISCLOSURE: Byoung Lee, No Financial Disclosure Information; No Product/Research Disclosure Information