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Abstract: Poster Presentations |

INTERLEUKIN-2 RECEPTOR LEVELS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS BEFORE AND AFTER ANTITUBERCULOUS CHEMOTHERAPY FREE TO VIEW

Ahmed G. Egazzar, MD; Sohair A. Rahman, MD; Tawfik E. Elsaid, MBBCh, MD*; Hussam E. Mostafa, MD; Mohamed Hussain, MD
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Alsalama Hospital, Abu Dhabi, United Arab Emirates


Chest


Chest. 2007;132(4_MeetingAbstracts):638c-639. doi:10.1378/chest.132.4_MeetingAbstracts.638c
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Abstract

PURPOSE: It has been long recognized that T Lymphocytes are essential in the immunity against tuberculosis. This study aimed to evaluate serum levels of interleukin-2 receptors in patients with active pulmonary tuberculosis and their levels change following antituberculosis chemotherapy.

METHODS: Twenty five patients with newly diagnosed active pulmonary tuberculosis and fifteen adult healthy control subjects had participated in this study. Plain X-ray chest, postero-anterior and lateral views (at diagnosis and after two months of start of treatment); tuberculin skin testing (by Mantoux Method); sputum for acidfast bacilli by Zeil Nelsen stain (at diagnosis and every month after start of treatment); and estimation of serum soluble interleukin-2 receptor levels (before, after 3 months and after 6 months of treatment start) were done to all subjects. All patients were treated with standard anti-tuberculosis drugs (INH-RIF-ETB-PZ).

RESULTS: Serum levels of interleukin-2 receptors (IL-2R, u/ml) were significantly higher in patients group with a statistically highly significant difference between patients (pretreatment; three and six months after treatment) and control subjects (p<0.05). Also,there was a highly significant difference in serum interleukin-2 receptor levels in patients at different periods of treatment (pretreatment, 3 and 6 months after treatment) (p<0.05). This difference was, also, directly proportional to the differences in ESR, total leucocytic count and lymphocytes.

CONCLUSION: The IL-2R serum levels were significantly higher in patients with active pulmonary tuberculosis and gradually decline with anti- tuberculosis chemotherapy, but does not return to the normal levels at the end of the treatment course. These high IL-2R levels were directly proportional to the disease severity.

CLINICAL IMPLICATIONS: Use of serum interleukin-2 receptors(s IL-2R) levels as an assistant test in the diagnosis of pulmonary tuberculosis especially smear-negative patients; diagnosis of extra-pulmonary tuberculosis; in assessment of severity of the disease; follow up of the disease; assessment of the efficacy of treatment with different regimens and development of drug resistance; diagnosis of reactivity of the disease and assessment of new drugs used in treatment of tuberculosis.

DISCLOSURE: Tawfik Elsaid, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, October 24, 2007

12:30 PM - 2:00 PM


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