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Abstract: Poster Presentations |

THE PATHOLOGICAL COMPARISON OF THE LUNGS FROM SARS AND CLASSIC ARDS FREE TO VIEW

Guangfa Wang, MD, FCCP*; Cheng Zhang, MD; Qin Lin, MD; Xiuying Tang, MD; Feng Li, PhD; Yan Tang, PhD; Jiang Gu, PhD
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Peking University First Hopital, Beijing, Peoples Rep of China


Chest


Chest. 2007;132(4_MeetingAbstracts):636a. doi:10.1378/chest.132.4_MeetingAbstracts.636a
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Abstract

PURPOSE: To explore the characteristics of SARS Coronovirus-induced lung injury by comparing the protein expression of CD34,VEGF and AQP-1 in SARS lungs with those in non-SARS lung injury.

METHODS: Lung autopsy specimens, from 7 diagnosed SARS cases and 6 classic ARDS cases, were examined by routine Hematoxylin and Eosin (HE) and immunohistochemistry stain of CD34, VEGF and AQP-1. Normal lung from 4 patients with lung cancer was as the control. The staining density was acquired and compared between SARS and non SARS group.

RESULTS: The blood vessels in SARS lungs outlined the alveolus clearly, CD34 mean optical density(M.O.D) was 0.2843 ± 0.1033,which was significantly higher than that of non-SARS lungs(0.1297 ± 0.0073,P = 0.0074). The M.O.D of VEGF of the two groups had no statistical difference. The M.O.D of AQP-1 in SARS and non-SARS lung was significantly decreased but without significant difference between the two groups. M.O.D for SARS was 0.09710±0.02413, and 0.09830±0.01780 for classic ARDS(p=0.922).

CONCLUSION: The injury to pulmonary endothelial cells in SARS was not as serious as in classic ARDS. The expression of VEGF and AQP-1 was very similar to that of classic ARDS. The study might be contributable to the understanding of lung injury caused by SARS.

CLINICAL IMPLICATIONS: The study revealed some features of SARS virus induced lung injury.These will perhaps explain the clinical features and responsiveness to treatments of SARS.

DISCLOSURE: Guangfa Wang, None.

Wednesday, October 24, 2007

12:30 PM - 2:00 PM


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