PURPOSE: PH has a multifactorial etiology and is a major cause of morbidity and mortality among patients. Obstructive sleep apnea (OSA) is a possible contributor for PH, but there have been no conclusive studies on BMI alone causing PH. We performed a retrospective study on the relationship of BMI and PH.
METHODS: Medical records of patients who had sleep studies in our institution over the past one year were reviewed. Patients were divided into two groups based on BMI (patients who are morbidly obese and patients who are not morbidly obese). Two-dimensional Echocardiography reports of mean pulmonary artery pressure (PAP) were obtained, together with other data like age, sex, race, co morbidities, respiratory disturbance index (RDI), Epworth sleepiness scale (ESS), and neck circumference.
RESULTS: The mean BMI of patients belonging to the morbidly obese group is 49.72 (SD 4.83), with mean PAP of 30.62 (SD 11.79), and mean RDI of 21.39 (SD 27.17). For the other group the mean BMI is 33.46 (SD 5.07), with mean PAP of 28.2 (SD 4.71), and mean RDI of 63.52 (SD 44.06). Using one-way ANOVA, there is no statistically significant difference in the MPAP among the two groups, with a p-value of 0.663. However, there is a statistically significant correlation between BMI and RDI of our patients with p-value of 0.008. There is also a statistically significant correlation between neck circumference and RDI among our patients with p-value of 0.037.
CONCLUSION: Our study indicates that there is no statistically significant correlation between BMI and MPAP. Further investigation, in the form of a prospective, case-control study, is needed to determine is BMI alone has a causative effect on PH. Our study also shows that there is linear correlation between RDI and BMI, and neck circumference and BMI.
CLINICAL IMPLICATIONS: Body mass index (BMI) and risk for pulmonary hypertension (PH).
DISCLOSURE: Roberto Santos, No Financial Disclosure Information; No Product/Research Disclosure Information