Abstract: Poster Presentations |


Stanton T. Siu, MD, FCCP*; Carlos Iribarren, MD, PhD; Natalia Udaltsova, PhD; Rajeeva Ranga, DO; James L. Chen, DO; Arthur L. Klatsky, MD
Author and Funding Information

Kaiser Permanente Medical Care Program, Oakland, CA


Chest. 2007;132(4_MeetingAbstracts):614b-615. doi:10.1378/chest.132.4_MeetingAbstracts.614b
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PURPOSE: Limited data suggest that moderate alcohol drinkers may have better pulmonary function test (PFT) performance than abstainers. Important potential confounders include a drinking-smoking correlation, the inverse relation of drinking with coronary disease, and inclusion of former drinkers who quit because of illness among non-drinkers. More data are needed.

METHODS: We studied the alcohol-PFT relation in 177, 637 members of a Northern California comprehensive health plan who took health examinations between 1964 and 1973. A questionnaire item asked for “usual number of drinks in the past year” with options of “none” (21.4%), <2 drinks per day (60.7%), 3-5 per day (8.0%), and 6+ per day (2.3%); 8.6% supplied incomplete data. Tests included FEV1 and FVC. The health history queries included 47 items indicative of possible cardio-respiratory (CR) illness; classification was “CR yes” for any positive responses (61.0%) and “CR no” for no positive responses (39.0%). Using FEV1/FVC <0.7 (vs >=0.7) as an endpoint we performed logistic regression analyses with nondrinkers as reference for alcohol categories, plus age, sex, ethnicity, smoking, education, body mass index, and CR (yes/no) in most models.

RESULTS: For all persons adjusted Odds Ratios (OR) and [95% Confidence Intervals] vs nondrinkers for FEV1/FVC <0.7 were: <2 drinks/day = 0.82 [0.79-0.85, p <0.001], 3-5 drinks/day = 0.90 [0.86-0.95; p <0.001], 6+ drinks/day = 1.09 [1.00-1.08, p <0.05]. This J-curve for the alcohol-PFT relation was consistent in multiple stratified models. Examples of OR for <2 drinks per day vs nondrinkers in selected strata follow: men = 0.83; women = 0.81, whites = 0.83, African Americans = 0.83, Asian Americans = 0.86, never smokers = 0.82, exsmokers = 0.85, smoke <1 ppd = 0.89, smoke 1+ppd = 0.87, CR yes = 0.84; CR no = 0.79.

CONCLUSION: These data show that independent of smoking and evidence of lung or heart disease, light to moderate drinkers are less likely to have an abnormal FEV1/FVC.

CLINICAL IMPLICATIONS: Drinking light to moderate amounts of alcoholic beverages may have benefit for lung function.

DISCLOSURE: Stanton Siu, None.

Wednesday, October 24, 2007

12:30 PM - 2:00 PM




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