0
Abstract: Poster Presentations |

THE COMPARISON BETWEEN 400 MICROGRAM VS 200 MICROGRAM INHALED SALBUTAMOL FOR BRONCHODILATOR REVERSIBILITY TESTING AMONG PATIENTS RECEIVING SPIROMETRIC EVALUATION FREE TO VIEW

Theerasuk Kawamatawong, MD*; Supattra Siriket, BSc; Kulanee Vongvivat, BSc; Sumalee Kiatboonsri, MD; Porntip Chatchaipun, BSc
Author and Funding Information

Ramathibodi Hospital, Bangkok, Thailand


Chest


Chest. 2007;132(4_MeetingAbstracts):614a. doi:10.1378/chest.132.4_MeetingAbstracts.614a
Text Size: A A A
Published online

Abstract

PURPOSE: To evaluate the efficacy and safety of 400 μg inhaled Salbutamol as bronchodilator for reversibility testing in spirometric evaluation (from new ATS/ERS recommendation for standardization of spirometry 2005).

METHODS: Prospective randomized controlled trial with 200 and 400 μg inhaled Salbutamol in patients received spirometric evaluation at pulmonary division between October 2006- March 2007. Routine pre and postbronchodilator spirometric parameters and pulse rate (by pulse oximetry) were recorded at 5,10,15,30 and 60 minute respectively. Palpitation and tremor were also noted. Electrocardiography will be performed when pulse rate is above 100/min.

RESULTS: There were 232 patients enrolled, with 113 and 119 of them received 200 and 400μg inhaled Salbutamol during spirometric evaluation respectively. Base-line diagnoses, demographic and spirometric parameters were not different between the two groups.Post bronchodilator, patients in both groups showed no statistical significant differences of the following parameters: 1) FVC, FEV1, FEF25-75 (%predicted) and FEV1/FVC ratio (84±16 vs 85±17, p=0.764; 77±22 vs 74±19, p=0.425; 56.2±30 vs 50.7±29, p=0.14; and 72.4±13.4 vs 70.3±14.6, p=0.249 respectively). 2) Pulse rates at all measured intervals. 3) Side effects of palpitation and tremor. However, a small but non-significant number of cardiac arrhythmia was observed in 4 patients (1 in 200μg and 3 in the 400μg groups respectively).

CONCLUSION: 200 and 400μg inhaled Salbutamol exhibited equivalent bronchodilating effects in routine spirometric evaluations with minimal side effect.

CLINICAL IMPLICATIONS: Since 200 and 400μg inhaled Salbutamol are equally effective, higher dose (400μg) inhaled Salbutamol should be used cautiously in patients who are vulnerable to cardiac arrhythmia.

DISCLOSURE: Theerasuk Kawamatawong, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, October 24, 2007

12:30 PM - 2:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543