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Abstract: Poster Presentations |

DIABETES MELLITUS FOLLOWING LUNG TRANSPLANTATION: INCIDENCE AND RISK FACTORS FREE TO VIEW

David Shitrit, MD*; Jacobs Ollech, MD; Anat Amital, MD; Mordechai R. Kramer, MD, FCCP
Author and Funding Information

Rabin Medical Center, Jerusalem, Israel


Chest


Chest. 2007;132(4_MeetingAbstracts):597. doi:10.1378/chest.132.4_MeetingAbstracts.597
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Abstract

PURPOSE: Diabetes Mellitus is a common and potentially serious complication of solid organ transplantation. We investigaste its incidence and risk factors in lung transplant recipients.

METHODS: The files of 119 consecutive patients who underwent lung transplantation from 1998 to september 2004 were reviewed. Patients were divided into 3 groups according to diabetes status: pretransplant diabetes, post-transplant diabetes mellitus (PTDM, and patients without diabetes. All were treated with a tacrolimus-based regimen.

RESULTS: Twent-three patients (19.3%) had pretransplant DM and 34 of the remaining 96 patients (35.4%) had PTDM. Twenty percent of the sample had diabetes at 6 months after surgery and 23% at 12 months. Compared to the no-diabetes group, the PTDM was characterized by older age (57 vs. 53, p=0.009) higher BMI (26 vs. 24, p=0.001), shorter time from diagnosis to transplantation (21 vs. 28 months, p=0.007, higher rate of CMV infection and higher rate of acute rejection and hyperglycemia.

CONCLUSION: PTDM is a common complication of lung transplantation recieving tacrolimus-based immunosuppression. The risk is greatest in older or obese recipients and in recipients with more rejection episodes.

CLINICAL IMPLICATIONS: to be aware to the high incidence of Diabetes mellitus in lung transplant recipients.

DISCLOSURE: David Shitrit, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, October 24, 2007

12:30 PM - 2:00 PM


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