PURPOSE: Diabetes Mellitus is a common and potentially serious complication of solid organ transplantation. We investigaste its incidence and risk factors in lung transplant recipients.
METHODS: The files of 119 consecutive patients who underwent lung transplantation from 1998 to september 2004 were reviewed. Patients were divided into 3 groups according to diabetes status: pretransplant diabetes, post-transplant diabetes mellitus (PTDM, and patients without diabetes. All were treated with a tacrolimus-based regimen.
RESULTS: Twent-three patients (19.3%) had pretransplant DM and 34 of the remaining 96 patients (35.4%) had PTDM. Twenty percent of the sample had diabetes at 6 months after surgery and 23% at 12 months. Compared to the no-diabetes group, the PTDM was characterized by older age (57 vs. 53, p=0.009) higher BMI (26 vs. 24, p=0.001), shorter time from diagnosis to transplantation (21 vs. 28 months, p=0.007, higher rate of CMV infection and higher rate of acute rejection and hyperglycemia.
CONCLUSION: PTDM is a common complication of lung transplantation recieving tacrolimus-based immunosuppression. The risk is greatest in older or obese recipients and in recipients with more rejection episodes.
CLINICAL IMPLICATIONS: to be aware to the high incidence of Diabetes mellitus in lung transplant recipients.
DISCLOSURE: David Shitrit, No Financial Disclosure Information; No Product/Research Disclosure Information