PURPOSE: To improve the diagnosis of pulmonary mucosa associated lymphoid tissue(MALT) lymphoma.
METHODS: From June 1998 to June 2006, 13 cases were pathologically diagnosed as pulmonary MALT lymphoma through bronchoscopy, VATS pleural or lung biopsy, or open biopsy of lung in Shanghai Pulmonology Hospital. We analyzed their clinical manifestations, radiologic findings and invasive investigations, and made a thorough review of medical literature, too.
RESULTS: Among the 13 patients were 9 males and 4 females, with an average age of 55 years old. The average duration of disease was 14 months, ranging from 1.5 to 108 months. Clinical manifestations were mild and non-specific, including cough, chest pain, short of breath, hemoptysis, fever, loss of weight, etc. Some were found through routine examination. Chest radiography mostly showed multiple lesions, more often bilaterally (7/13). The radiologic morphology was diversified, including mass (2/13), nodule (2/13), air brochogram within consolidation (9/13) and pleural efusion (4/13). Bronchoscopy could find bronchial stenosis and inflammation (6/13).
CONCLUSION: Pulmonary MALT is relatively rare, and is more common in middle-and old-aged males. The progression of the disease is slow and its clinical features are non-specific.
CLINICAL IMPLICATIONS: Physicians should keep in mind the possibility of this disorder when chest CT shows consolidation with airbronchogram, mainly bilaterally, or when bronchoscopy demonstrates bronchial stenosis and inflammation, and the lesions don’t resolve after anti-infective treatment. If pulmonary MALT is suspected, the physician should try to get a pathological diagnosis.
DISCLOSURE: Haiqing Chu, No Financial Disclosure Information; No Product/Research Disclosure Information