PURPOSE: Sarcoidosis can involve any part of the eye. It may pre-date the appearance of lung sarcoidosis but may as well occur later during the course of the disease. The focus of this study is to analyze the possible clinical manifestations of the eye sarcoidosis in a large population of sarcoidosis patients.
METHODS: In the Institute of Pulmonary Diseases Clinical Center, Beograd, 910 biopsy positive sarcoidosis patients were analyzed. The follow up period was 11 years (1996-2006).Ophthalmologic examinations were done in the University Eye Clinic, Beograd, Serbia.
RESULTS: Out of this group we found 162/910 (18%) of patients with different forms of ocular involvement. (65, 5% female patients, 34, 5% male patients).The majority of our patients had intermediary granulomatous uveitis (44%); Multifocal periphlebitis (37%); Orbital granulomas (19%); Anterior granulomatous uveitis (19%); Lachrymal gland involvement (10%); Conjunctive granulomatous inflammation (6%); Optical nerve lesions were found in 5%. All patients hade pulmonary sarcoidosis stage 0-4 (most of them stage I and II of the lung disease: 45, 5% and 33, 7%). 54% of patients in the analyzed group were patients with chronic sarcoidosis (pulmonary and extra pulmonary) persisting for years. 35% of patients with ocular disease have acute beginning but later chronic course of sarcoidosis (during the follow up period).Only 10% of our patients with ocular sarcoidosis have acute sarcoidosis with the typical clinical manifestations.
CONCLUSION: Eye sarcoidosis may occur in any part of the eye, with different clinical manifestations. It may appear as the first sign of sarcoidosis or follow the other clinical manifestations of the disease. The eye involvement is a serious form of sarcoidosis, not only for its long lasting unpleasant symptoms and signs but for the definite complications including the loss of vision.
CLINICAL IMPLICATIONS: It is very important that all sarcoidosis patients are evaluated for eye disease, and that sarcoidosis should be considered as the most important cause of abnormal eye finding.
DISCLOSURE: Violeta Vucinic, No Financial Disclosure Information; No Product/Research Disclosure Information