PURPOSE: Sarcoidosis predisposing to malignancy has been debated in the literature. One Danish study (historically exhibiting milder sarcoidosis), found no increased occurrence of lung cancer or malignant lymphoma. African American (AA) sarcoidosis pts (presumed to have more severe sarcoidosis) may be disproportionately impacted by cancer. We therefore, set out to access the types and frequency of cancers in our population.
METHODS: Patients with diagnostic codes for neoplasms (ICD-9 codes 140-239) were obtained from our sarcoidosis database of 283 patients constructed from data, between 11/1999-12/2003, contained within the in and out patient databases of the Grady Health System. Confirmation of sarcoidosis was obtained from electronic pathology and medical records documenting patients with biopsy proven (B+), or medical record history (H+) of sarcoidosis.
RESULTS: 27 patients (19 F, 8 M) had ICD-9 codes for neoplasms, with malignant (6), benign (5), or no (16) pathology documented. Malignant biopsies were from the kidney, finger, thyroid, colon, breast, and tonsil. Benign biopsies were from the uterus (3pts), colon, and spleen. Pts were 54 +/- 12 yrs at time of cancer diagnosis which occurred at about 6 yrs post sarcoidosis diagnosis.
CONCLUSION: 11/27 (41%) pts had confirmed pathology for neoplasms and malignant neoplasms included a wide range of organs.
CLINICAL IMPLICATIONS: A multiorgan system distribution of cancer may follow a similar distribution for sarcoidosis in AA patients.
DISCLOSURE: Binu George, No Financial Disclosure Information; No Product/Research Disclosure Information