PURPOSE: Sleep quality in an IPF sample is impaired(1). Obstructive sleep apnea syndrome (OSAS) may contribute to this impairment.
METHODS: We administered the Berlin Questionnaire (a validated instrument for identifying risk of OSAS(2))to an IPF sample. Subjects completed the instrument during an IPF support group meeting in Charleston, SC in an IRB approved protocol. Data was gathered from 21 IPF subjects; two-thirds (n=14/21) completed the instrument.
RESULTS: The mean age of subjects was 68(6.5)y (mean ± SD)and their mean BMI was 28.0(4.0) kg/m2. The majority (79%, n=11/14) were both at high risk for OSAS and hypertensive (79%, n=11/14). All reported snoring and 86 %(n=12/14) habitually so. 93% (n=13/14) reported that snoring disturbed others. 57% (n=8/14) reported at least one monthly episode of apnea. 92.8% (n=13/14) reported fatigue on waking and daytime fatigue at least monthly. 6 subjects (43%)reported driving while asleep. Only 21% (n=3/14) were obese (BMI ≥30 kg/m2).
CONCLUSION: IPF subjects appear to be commonly at high risk for OSAS and much more so than historical controls(3).This risk is not explained by concomitant obesity.
CLINICAL IMPLICATIONS: OSAS is widely unrecognized in the general population and likewise in an IPF sample. OSAS in IPF patients may account for reversible daytime fatigue, possibly wrongly ascribed to IPF. IPF patients, with the benefit of earlier diagnosis are engaged in activities of daily living including driving. IPF patients who drive when asleep need education to curtail this dangerous behavior. IPF patients should be screened for OSAS. These data need replication in larger more representative samples of IPF.1.Ahmed QA et al. Sleep Quality in Patients with Idiopathic Pulmonary Fibrosis (IPF) Is Poor. AJRCCM 2007,175;A568 2. Netzer N et al. Using the Berlin Questionnaire to Identify Patients at Risk for the Sleep Apnea Syndrome. Ann In Med Oct 1999 131;7:485- 4913.Netzer NC et al. Sleep in Primary Care International Study group. Prevalence of symptoms and risk of sleep apnea in primary care. Chest 2003 Oct;124(4):1406-14.
DISCLOSURE: Qanta Ahmed, No Financial Disclosure Information; No Product/Research Disclosure Information