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Abstract: Poster Presentations |

HEMATOLOGIC PROFILE OF ALCOHOL-DEPENDENT PATIENTS WITH INVASIVE PNEUMOCOCCAL DISEASE FREE TO VIEW

Kelsey Gray, MD, MS*; Connie S. Price, MD; Allison L. Sabel, MD, PhD; Katie H. Overdier, BS; Robert Wolken, RRT; Ivor S. Douglas, MD
Author and Funding Information

Denver Health Medical Center, Denver, CO


Chest


Chest. 2007;132(4_MeetingAbstracts):555c-556. doi:10.1378/chest.132.4_MeetingAbstracts.555c
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Abstract

PURPOSE: Alcohol dependence is associated with bone marrow hypoplasia and an increased incidence of fatal invasive pneumococcal disease. We hypothesized that the hematologic profile of alcohol dependent patients with pneumococcal sepsis would reflect greater bone marrow suppression compared to non-alcoholics.

METHODS: Patients with blood cultures positive for Streptococcus pneumoniae and meeting two SIRS criteria treated at Denver Health between January 1, 2003 and December 31, 2006 were included. Those with known malignancy were excluded. First and sequential daily complete blood counts were compared with non-alcohol dependent patients. Alcohol dependence was identified using ICD-9 codes.

RESULTS: Demographics were comparable between groups (Table). Alcohol dependence was associated with lower values for the first three sequential white blood cell counts (103/mm3): WBC 1 (11.8 ± 1.5 vs. 16.8 ± 1.1, p 0.009), WBC 2 (9.2 ± 1.3 vs. 14.5 ± 1.1, p 0.004), WBC 3 (7.9 ± 1.1 vs. 12.2 ± 0.9, p 0.005). Moreover, those with alcohol dependence had lower sequential platelet counts: PLT 1 (163 ± 19 vs. 231 ± 20, p 0.03), PLT 2 (139 ± 18 vs. 205 ± 17, p 0.014), PLT 3 (137 ± 18 vs. 205 ± 18, p 0.015). No difference was observed for hemoglobin.

CONCLUSION: Patients with invasive pneumococcal infections and alcohol dependence have lower white blood cell and platelet counts compared with non-alcoholics, consistent with hematopoetic dysfunction.

CLINICAL IMPLICATIONS: Alcohol may cause relatively greater immunodeficiency, resulting in enhanced morbidity and mortality from invasive pneumococcal disease.

DISCLOSURE: Kelsey Gray, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, October 24, 2007

12:30 PM - 2:00 PM


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