PURPOSE: Forced vital capacity (FVC), metabolic syndrome (MetS), and diabetes (DM) are associated with cardiovascular disease (CVD) morbidity and mortality. It is not clear as to the extent to which FVC contributes additionally to CVD risk in persons with MetS or DM.
METHODS: We examined 4,272 (projected to 43.2 million) U.S. adults aged 18–79 in the Third National Health and Nutrition Examination Survey (NHANES III), non-smokers and without known obstructive lung disease, the association of FVC with the pre-existing CVD in persons with and without MetS and DM. Multiple logistic regressions examined the odds ratio (OR) (with 95% confidence interval [CI]) of CVD (myocardial infarction, stroke, heart failure, angina, or peripheral arterial disease) in relation to quartile (Q) of percent predicted FVC stratified by the presence of MetS/DM.
RESULTS: The odds of CVD in persons in FVC Q2 (92.5% < FVC < 100.3%) and lowest FVC Q1 (< 92.5%) quartiles was highest in DM (OR=2.74 [1.02–7.38] and OR=3.14 [1.52–6.47], respectively), compared to persons with no disease in FVC Q4 (>108.6%) (reference group). Similar results among those with MetS in FVC Q1 were noted (OR=2.14 [1.25–3.68]). Findings persisted for those with MetS in FVC Q1 (OR=1.89 [1.07–3.33]) and DM FVC Q1 (OR=2.61 [1.25–5.45]) after adjustment for age, sex, ethnicity, total cholesterol, and body mass index.
CONCLUSION: We demonstrate an increased likelihood of CVD with lower FVC in persons with MetS and DM that is independent of age, body size, and other factors. Prospective investigation with CVD morbidity and mortality endpoints are needed to confirm these observations.
CLINICAL IMPLICATIONS: FVC measurement may be helpful to further stratify risk. Low FVC in DM and MetS is a predictor for CVD in non-smoking population.
DISCLOSURE: Hwa Lee, No Financial Disclosure Information; No Product/Research Disclosure Information