PURPOSE: To compare the impact of Isolated Hypertriglyceridemia (IH) versus other lipid profile abnormalities (OLA) on the severity and short-term prognosis of acute coronary syndromes (ACS) patients.
METHODS: We analized 781 patients consecutively admitted for ACS, in a single coronary care unit, from June/05 to June/06. Patients were divided into two groups: Group 1 - 221 patients with IH (triglycerides > 150 mg/dl, total cholesterol < 200 mg/dl and LDL-cholesterol < 160 mg/dl) and Group 2 –362 patients with OLA (total cholesterol ≥ 200 mg/dl or LDL-cholesterol ≥ 160 mg/dl associated or not with hypertriglyceridemia). Patients with normal lipid profile were excluded.
RESULTS: Group 1 had more male patients (78.3% versus 66.6%) and a higher prevalence of diabetes than Group 2. Regarding ACS severity, no significant differences were observed in the prevalence of STEMI, TIMI risk score, number of vessels with significant stenosis or length of stay. There were no significant differences in peak troponin-I, peak C-reactive protein or creatinine clearance between groups. Group 1 had lower peak creatinine kinase MB (79.0 ± 128.0 versus 101.0 ± 154.0, p < 0.05) but higher in-hospital mortality (4.5% versus 1.1%, p < 0.01). IH patients had lower HDL cholesterol and higher haemoglobin A(1c).
CONCLUSION: In an ACS population, the presence of IH is associated with a worse short-term prognosis than Hypercholesterolemia.
CLINICAL IMPLICATIONS: It has been well established that Hypercholesterolemia is a significant risk factor for acute coronary syndromes. However, the independent relationship between Isolated Hypertriglyceridemia and vascular risk remains controversial.
DISCLOSURE: Natalia Antonio, No Financial Disclosure Information; No Product/Research Disclosure Information