PURPOSE: Our interest in this study is to present our experience about the efficacy of Intrabronchial Chemotherapy in palliative care and survival of patients with inoperable Lung Cancers.
METHODS: : Fifty patients were studied (36 men, 14 women). All of them diagnosed with inoperable lung cancer. According to the histologic report they were categorized to 3 groups of, Adenocarcinoma (48%), Squamous cell carcinoma (32%), Non Small Cell Lung Cancer, unspecified (20%). Initial symptoms included, dyspnea (94%), cough (90%), sputum (80%), non massive hemoptysis (68%), fever and chills (56%), massive Hemoptysis (4%), chest pain (66%). All of the procedures performed via Olympus BF type 200 videobronchoscope. Cisplatin with the concentration of 50 mg/100 cc was used for all the cases as the chemotherapeutic solution. Maximum Four mg cisplatin per cm2 of tumor mass was injected intratumorally (Totally 20 cc). These procedures were performed weekly for 4 times. If patient didn’t have Radiotherapy indication this procedure performed Monthly.
RESULTS: At the end of the 4 th session of local chemotherapy, symptoms relief was seen in 52% of patients. Average survival time in the worst condition was 3 months and in the best condition was 15 months.
CONCLUSION: We strongly suggest Endobronchial Chemotherapy with cisplatin in palliation of inoperable Endobronchial malignant lesion.
CLINICAL IMPLICATIONS: There was no complication in our study.
DISCLOSURE: HamidReza Jabbardarjani, None.