PURPOSE: Asthma is a chronic inflammatory disorder of the airways in which many cells play a role, in particular mast cells, eosinophils (Eo), and T lymphocytes. Eosinophyls have an important role in the pathogenesis of bronchial asthma (BA). The following of their count and mediators in peripheral blood and BAL could be employed as a marker of the inflammation in asthmatic patients.
METHODS: We followed 30 patients with BA, treated with inhaled corticosteroids (IKS) (Spray Beclomethasone dipropionate) in doses of 1000-2000mg per day. We followed the Eo count, ECP and IL-5 in peripheral blood at the beginning of the study, after 2 and 6 months of the anti-inflammatory therapy.
RESULTS: We found a decrease of the Eo count from 292.66 ×106/l to 270 ×106/l, serum level of ECP from 22.92 to 19.36mg/l, and serum level of IL-5 from 44.94 to 37.84 pg/ml at the first control (after 2 months), and Eo count to 224.33 ×106/l, ECP to 14.47mg/l, and IL-5 to 30.44 pg/ml, 6 months from the treatment. The analysis of variance showed statistical significance of p<0.05 for this reduction.
CONCLUSION: We concluded that inhaled corticosteroids decrease the inflammation in BA and the eosinophyls, ECP and IL-5 are just another parameters for a follow up of this effect.
CLINICAL IMPLICATIONS: Biological markers of the inflammation can be used as a diagnostic parameter, and as e parameter for follow up of the therapy in asthmatics.
DISCLOSURE: Deska Dimitrievska, None.