PURPOSE: Cys-leukotrienes (LTs) are products of the arachidonic acid cascade, and synthesised by 5-lipoxigenase in inflammatory cells, particularly in eosinophils. Urinary leukotriene E4 concentration (LTE4), that reflects the whole body production of the cys-leukotrienes, is particularly increased in patients with aspirin-intolerant asthma (AIA). Aim: to compare the Basal Membrane Thickness (BMT); BAL eosinophil count (EOS), Eosinophil Cationic Protein (ECP), and urinary LTE4 in patients with nasal polyps and ASA-intolerant, with or without bronchial asthma.
METHODS: Methods: after their informed consent, 14 moderate asthmatics with nasal polyps (ANP, 18–57y, 7 m., FEV1 = 70.6% pred. ± 8.9sd) and 8 patients with nasal polyps without asthma (NP, 22 −54 y, 4 m, FEV1 = 99.8 % pred. ± 7.6sd, negative MCh challenge) all non-smoker, underwent an endobronchial biopsy + BAL. Urine were collected in the morning for the quantitative LTE4 immunoenzimatic assay (Cayman Chemical, Mi, USA). Statistics: t test, p<0.05 accepted.
RESULTS: Risults in tab.1.
CONCLUSION: The extent of eosinophilic inflammation proves significantly greater in moderate asthmatics.
CLINICAL IMPLICATIONS: Nasal polyps should be regarded as a condition leading to a quicker impairment and remodelling of bronchial structures.
DISCLOSURE: Roberto Dal Negro, No Financial Disclosure Information; No Product/Research Disclosure Information