0
Abstract: Slide Presentations |

PROLONGED INFUSION OF CLEVIDIPINE RESULTS IN SAFE AND PREDICTABLE BLOOD PRESSURE CONTROL IN PATIENTS WITH ACUTE SEVERE HYPERTENSION FREE TO VIEW

J Varon, MD, FCCP*; W. Peacock, MD; N. Garrison, MD; R. Ebrahimi, MD; L. Dunbar, MD; P. Acosta, MD; C. Pollack, MD
Author and Funding Information

University of Texas Health Science Center, Houston, TX


Chest


Chest. 2007;132(4_MeetingAbstracts):477b. doi:10.1378/chest.132.4_MeetingAbstracts.477b
Text Size: A A A
Published online

Abstract

PURPOSE: Severe hypertension is common and requires rapid, predictable and safe reduction of blood pressure (BP). Clevidipine (CLV) is a novel arterial-selective calcium antagonist with an ultra-short half life (t½ ∼ 1 min). The purpose of this predefined analysis from the VELOCITY trial was to assess the safety and efficacy of a prolonged infusion of CLV in severe hypertension (HTN).

METHODS: An open-label, single-arm trial was performed at 11 centers across the US. Patients presenting in the emergency department with persistent systolic BP (SBP) >180 or diastolic BP >115 mmHg were eligible. SBP target ranges to be achieved within the first 30 min were selected and patients received CLV infusion via a peripheral line using a non-weight based titration algorithm. Patients were monitored with a BP cuff. The infusion rate was maintained or further titrated after 30 min to the desired long-term (≥18 h) SBP target.

RESULTS: Of the 126 patients in the safety population, 117 (mITT population) were included in the efficacy analysis. The mean age was 53 yrs, 51% were female and 77% were black. Almost all patients (97%) had a history of HTN. Mean baseline SBP was 203 mmHg. After initiating CLV the mean SBP rapidly decreased during the titration period: -12 mmHg (-6%) at 3 min, -34 mmHg (-16.5%) at 15 min and -45 mmHg (-21%) at 30 min. Median time to patients achieving a 15% reduction in SBP was 9.5 min. At 18 h the BP reduction was -55 mmHg (-27%) from baseline. Throughout 18 h, target SBP was maintained at a steady CLV infusion rate. A modest 9 bpm increase in HR was seen at 30 min. After 30 min and up to 18 h HR trended back to baseline. AEs were reported in 10% of patients. No hypotensive events were reported.

CONCLUSION: CLV was safe and effective after prolonged infusion in patients with acute severe HTN.

CLINICAL IMPLICATIONS: CLV offers rapid, predictable and safe BP control in patients with acute severe HTN.

DISCLOSURE: J Varon, Consultant fee, speaker bureau, advisory committee, etc. Consultant and Advisor: The Medicines Company; Other Investigator: The Medicines Company; Product/procedure/technique that is considered research and is NOT yet approved for any purpose. Clevidipine for acute, severe hypertension

Tuesday, October 23, 2007

2:30 PM - 4:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543